Scientific Contributions
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2024
Pharmaceutical Digital Design: From Chemical Structure through Crystal Polymorph to Conceptual Crystallization Process, C. L. Burcham, M. F. Doherty, B. G. Peters, S. L. Price, M. Salvalaglio, S. M. Reutzel-Edens, L. S. Price, R. K. R. Addula, N. Francia, V. Khana, Crystal Growth Des., 24, 5417-5438. DOI: 10.1021/acs.cgd.3c01390 [Download PDF]
The Seventh Blind Test of Crystal Structure Prediction: Structure Generation Methods, L. M. Hunnisett, et al., Acta Cryst., B80, DOI: 10.1107/S2052520624007492 [Download PDF]
The Seventh Blind Test of Crystal Structure Prediction: Structure Ranking Methods, L. M. Hunnisett, et al., Acta Cryst., B80, DOI: 10.1107/S2052520624008679 [Download PDF]
2023
Predicting crystal form stability under real-world conditions, D. Firaha, Y. M. Liu, J. van de Streek, K. Sasikumar, H. Dietrich, J. Helfferich, L. Aerts, D. E. Braun, A. Broo, A. G. DiPasquale, A. Y. Lee, S. Le Meur, S. O. Nilsson Lill, W. J. Lunsmann, A. Mattei, P. Muglia, O. D. Putra, M. Raoui, S. M. Reutzel-Edens, S. Rome, A. Y. Sheikh, A. Tkatchenko, G. R. Woollam, M. A. Neumann, Nature, 623, 324-328. DOI: 10.1038/s41586-023-06587-3
Do metastable polymorphs always grow faster? Measuring and comparing growth kinetics of three polymorphs of tolfenamic acid, P. Sacchi, P. Neoptolemou, R. J. Davey, S. M. Reutzel-Edens, A. J. Cruz-Cabeza, Chem. Sci., 14, 11775-11789. DOI: 10.1039/D3SC02040A [Download PDF]
2022
Computer-Aided Solid Form Design, S. M. Reutzel-Edens, CrystEngComm, DOI: 10.1039/D1CE90150H [Download PDF]
2021
The unexpected discovery of the ninth polymorph of tolfenamic acid, P. Sacchi, S. M. Reutzel-Edens, A. J. Cruz-Cabeza, CrystEngComm, 23, 3636-3647. DOI: 10.1039/D1CE00343G [Download PDF]
Crystal Morphology Modeling of Solvates and Hydrates of Organic Molecular Crystals: Olanzapine Solvate and Dihydrate, Y. Sun, S. M. Reutzel-Edens, R. M. Bhardwaj, M. F. Doherty, Crystal Growth Des., 21, 4871-4877. DOI: 10.1021/acs.cgd.1c00195
2020
Absorptive Dissolution Testing: An Improved Approach to Study the Impact of Residual Crystallinity on the Performance of Amorphous Formulations, S. S. Hate, S. M. Reutzel-Edens, L. S. Taylor, J. Pharm. Sci., 109, 1312-1323. DOI: 10.1016/j.xphs.2019.11.016
Influence of Drug-Silica Electrostatic Interactions on Drug Release from Mesoporous Silica-Based Oral Delivery Systems, S. S. Hate, S. M. Reutzel-Edens, L. S. Taylor, Mol. Pharm., 17, 3435-3446. DOI: 10.1021/acs.molpharmaceut.0c00488
Interplay of Adsorption, Supersaturation and the Presence of an Absorptive Sink on Drug Release from Mesoporous Silica-Based Formulations, S. S. Hate, S. M. Reutzel-Edens, L. S. Taylor, Pharm. Res., 37 (8), 1-18. DOI: 10.1007/s11095-020-02879-9
Symmetry in the Making, S. M. Reutzel-Edens, Nat. Chem., 12, 887-888. DOI: 10.1038/s41557-020-0547-8
Crystal Forms in Pharmaceutical Applications: Olanzapine, a Gift to Crystal Chemistry that Keeps on Giving, S. M. Reutzel-Edens, R. M. Bhardwaj, IUCrJ, 7, 955-964. DOI: 10.1107/S2052252520012683 [Download PDF]
Diabat Method for Polymorph Free Energies: Extension to Molecular Crystals, K. Kamat, R. Guo, S. M. Reutzel-Edens, S. L. Price, B. Peters, J. Chem. Phys., 153, 244105. DOI: 10.1063/5.0024727
2019
Accuracy and Reproducibility in Crystal Structure Prediction: The Curious Case of ROY, J. Nyman, L. Yu, S. M. Reutzel-Edens, CrystEngComm, 21, 2080-2088. DOI: 10.1039/C8CE01902A
Insight into Amorphous Solid Dispersion Performance by Coupled Dissolution and Membrane Mass Transfer Measurements, S. S. Hate, S. M. Reutzel-Edens, L. S. Taylor, Mol. Pharm., 16, 448-461. DOI: 10.1021/acs.molpharmaceut.8b01117
Inconvenient Truths about Solid Form Landscapes Revealed in the Polymorphs and Hydrates of Gandotinib, D. E. Braun, J. A. McMahon, R. M. Bhardwaj, J. Nyman, M. A. Neumann, J. van de Streek, S. M. Reutzel-Edens, Cryst. Growth Des., 5, 2947-2962. DOI: 10.1021/acs.cgd.9b00162
A Prolific Solvate Former, Galunisertib, Under the Pressure of Crystal Structure Prediction, Produces Ten Diverse Polymorphs, R. M. Bhardwaj, J. A. McMahon, J. Nyman, L. S. Price, S. Konar, I. D. H. Oswald, C. R. Pulham, S. L. Price, S. M. Reutzel-Edens, J. Am. Chem. Soc., 141, 13887-13897. DOI: 10.1021/jacs.9b06634 [Download PDF]
2018
Coamorphous API-Small Molecule Mixtures: Considerations in the Choice of Co-Formers for Enhancing Dissolution and Oral Bioavailability, A. Newman, S. M. Reutzel-Edens, G. Zografi, J. Pharm. Sci., 107, 5-17. DOI: 10.1016/j.xphs.2017.09.024 [Download PDF]
Evaluating Competing Intermolecular Interactions Through Molecular Electrostatic Potentials and Hydrogen-Bond Propensities, B. Sandhu, A. McLean, A. S. Sinha, J. Desper, A. A. Sarjeant, S. Vyas, S. M. Reutzel-Edens, C. B. Aakeröy, Cryst. Growth Des., 18, 466-478. DOI: 10.1021/acs.cgd.7b01458
Modeling Olanzapine Solution Growth Morphologies, Y. Sun, C. J. Tilbury, S. M. Reutzel-Edens, R. M. Bhardwaj, J. Li, M. F. Doherty, Cryst. Growth Des., 18, 905-911. DOI: 10.1021/acs.cgd.7b01389
A Random Forest Model for Predicting Crystal Packing of Olanzapine Solvates, R. M. Bhardwaj, S. M. Reutzel-Edens, B. F. Johnston, A. J. Florence, CrystEngComm, 20, 3947-3950. DOI: 10.1039/C8CE00261D
Crystal Structure Prediction is Changing from Basic Science to Applied Technology, J. Nyman, S. M. Reutzel-Edens, Faraday Discuss., 211, 459-476. DOI: 10.1039/C8FD00033F
Structure Searching Methods: General Discussion, M. Addicoat, C. Adjiman, M. Arhangelskis, G. J. O. Beran, G. Brandenburg, D. Braun, V. Burger, A. Burow, C. Collins, A. Cooper, G. Day, V. Deringer, M. S. Dyer, A. Hare, K. Jelfs, J. Keupp, S. Konstantinopoulos, Y. Li, Y. Ma, N. Marom, D. McKay, C. Mellot-Draznieks, S. Mohamed, M. Neumann, S. Nilsson Lill, J. Nyman, A. R. Oganov, S. Price, S. Reutzel-Edens, M.l. Ruggiero, G. Sastre, R. Schmid, J. Schmidt, C. Schön, P. Spackman, S. Tsuzuki, S. Woodley, S. Yang, Q. Zhu, Faraday Discuss., 211, 133-180. DOI: 10.1039/C8FD90030B
Crystal Structure Evaluation: Calculating Relative Stabilities and Other Criteria: General Discussion, M. Addicoat, C. Adjiman, M. Arhangelskis, G. J. O. Beran, D. Bowskill, G. Brandenburg, D. Braun, V. Burger, J. Cole, A. Cruz-Cabeza, G. Day, V. Deringer, R. Guo, A. Hare, J. Helfferich, J. Hoja, L. Iuzzolino, S Jobbins, N. Marom, D. McKay, J. Mitchell, S. Mohamed, M. Neumann, S. Nilsson Lill, J. Nyman, A. R. Oganov, P. Piaggi, S. Price, S. Reutzel-Edens, I. Rietveld, M. Ruggiero, M. Ryder, G. Sastre, C. Schön, C. Taylor, A. Tkatchenko, S. Tsuzuki, J. van den Ende, S. Woodley, G. Woollam, Q. Zhu, Faraday Discuss., 211, 325-381. DOI: 10.1039/C8FD90031K
Applications of Crystal Structure Prediction – Organic Molecular Structures: General Discussion, C. Adjiman, G. Brandenburg, D. Braun, J. Cole, C. Collins, A. I. Cooper, A. Cruz-Cabeza, G. Day, M. Dudek, A. Hare, L. Iuzzolino, D. McKay, J. Mitchell, S. Mohamed, S. Neelamraju, M. Neumann, S. Nilsson Lill, J. Nyman, A. R. Oganov, S. Price, A. Pulido, S. Reutzel-Edens, I. Rietveld, M. T. Ruggiero, C. Schön, S. Tsuzuki, J. van den Ende, G. Woollam, Q. Zhu, Faraday Discuss., 211, 493-539. DOI: 10.1039/C8FD90032A
2017
Unraveling Complexity in the Solid Form Screening of a Pharmaceutical Salt: Why So Many Forms? Why So Few? D. E. Braun, S. R. Lingireddy, M. D. Beidelschies, R. Guo, P. Müller, S. L. Price, S. M. Reutzel-Edens, Cryst. Growth Des., 17, 5349-5365. DOI: 10.1021/acs.cgd.7b00842 [Download PDF]
Absorptive Dissolution Testing of Supersaturating Systems: Impact of Absorptive Sink Conditions on Solution Phase Behavior and Mass Transport, S. S. Hate, S. M. Reutzel-Edens, L. S. Taylor, Mol. Pharm., 14, 4052-4063. DOI: 10.1021/acs.molpharmaceut.7b00740
Direct Observation of Templated Two-Step Nucleation Mechanism During Olanzapine Hydrate Formation, M. Warzecha, R. Guo, R. M. Bhardwaj, S. M. Reutzel-Edens, S. L. Price, D. A. Lamprou, A. J. Florence, Cryst. Growth Des., 17, 6382-6393. DOI: 10.1021/acs.cgd.7b01060
2016
Supersaturation Potential of Salts, Co-Crystal and Amorphous Forms of a Model Weak Base, L. A. e Sousa, S. M. Reutzel-Edens, G. A. Stephenson, L. S. Taylor, Cryst. Growth Des., 16, 737-748. DOI: 10.1021/acs.cgd.5b01341
Can Computed Crystal Energy Landscapes Help Understand Pharmaceutical Solids? S. L. Price, D. E. Braun, S. M. Reutzel-Edens, Chem. Comm., 52, 7065-7077. DOI: 10.1039/C6CC00721J [Download PDF]
The Potential of Computed Crystal Energy Landscapes to Aid Solid Form Development, S. L. Price, S. M. Reutzel-Edens, Drug Discovery Today, 21, 912-923. DOI: 10.1016/j.drudis.2016.01.014
2015
Assessment of the Amorphous Solubility of a Diverse Group of Drugs Using New Experimental and Theoretical Approaches, L. A. e Sousa, S. M. Reutzel-Edens, G. A. Stephenson, L. S. Taylor, Mol. Pharm., 12, 484-495. DOI: 10.1021/mp500571m
Navigating the Waters of Unconventional Crystalline Hydrates, D. E. Braun, L. H. Koztecki, J. A. McMahon, S. L. Price, S. M. Reutzel-Edens, Mol. Pharm., 12, 3069-3088. DOI: 10.1021/acs.molpharmaceut.5b00357 [Download PDF]
Facts and Fictions about Polymorphism, A. J. Cruz-Cabeza, S. M. Reutzel-Edens, J. Bernstein, Chem. Soc. Rev., 44, 8619-8635. DOI: 10.1039/C5CS00227C
2014
A Molecular Picture of the Problems in Ensuring Structural Purity of Tazofelone, L. S. Price, J. A. McMahon, S. R. Lingireddy, S. -F. Lau, B. A. Diseroad, S. L. Price, S. M. Reutzel-Edens, J. Mol. Struct., 1078, 26-42. DOI: 10.1016/j.molstruc.2014.01.014 [Download PDF]
Contrasting Polymorphism of Related Small Molecule Drugs Correlated and Guided by the Computed Crystal Energy Landscape, D. E. Braun, J. A. McMahon, L. H. Koztecki, S. L. Price, S. M. Reutzel-Edens, Cryst. Growth Des., 14, 2056-2072. DOI: 10.1021/cg500185h [Download PDF]
2013
Exploring the Experimental and Computed Crystal Energy Landscape of Olanzapine, R. M. Bhardwaj, L. S. Price, S. L. Price, S. M. Reutzel-Edens, G. J. Miller, I. D. H. Oswald, B. F. Johnston, A. J. Florence, Cryst. Growth Des., 13, 1602-1617. DOI: 10.1021/cg301826s
2009
Development of a Practical Synthesis of an Aminoindanol Derived M1 Agonist, M. M. Hansen, S. S. K. Borders, M. T. Clayton, P. C. Heath, S. P. Kolis, S. D. Larsen, R. J. Linder, S. M. Reutzel-Edens, J. C. Smith, S. L. Tameze, J. A. Ward, L. O. Weigel, Org. Proc. Res. Dev., 13, 198-208. DOI: 10.1021/op800243q
Synthesis, Crystallization and Biological Evaluation of an Orally Active Prodrug of Gemcitabine, D. M. Bender, J. Bao, A. H. Dantzig, W. D. Diseroad, K. L. Law, N. A. Magnus, J. A. Peterson, E. J. Perkins, Y. J. Pu, S. M. Reutzel-Edens, D. M. Remick, J. J. Starling, G. A. Stephenson, R. K. Vaid, D. Zhang, J. R. McCarthy, J. Med. Chem., 52, 6958-6961. DOI: 10.1021/jm901181h
2008
Characterization of the ‘Hygroscopic’ Properties of Active Pharmaceutical Ingredients, A. W. Newman, S. M. Reutzel-Edens, G. Zografi, J. Pharm. Sci, 97(3), 1047-1059. DOI: 10.1002/jps.21033
2006
Achieving Polymorph Selectivity in the Crystallization of Pharmaceutical Solids: Basic Considerations and Recent Advances, S. M. Reutzel-Edens, Curr. Opin. Drug Disc. Dev., 9(6), 806-815. [Download PDF]
2005
Diastereomeric Salt Resolution Based Synthesis of LY503430, an AMPA (a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid) Potentiator, N. A. Magnus, J. A. Aikins, J. S. Cronin, W. D. Diseroad, A. D. Hargis, M. E. LeTourneau, B. E. Parker, S. M. Reutzel-Edens, J. P. Schafer, M. A. Staszak, G. A. Stephenson, S. L. Tameze, L. M. H. Zollars, Org. Proc. Res. & Dev., 9, 621-628. DOI: 10.1021/op0500741
2003
Crystal Forms of LY334370 HCl: Isolation, Solid-State Characterization and Physicochemical Properties, S. M. Reutzel-Edens, R. L. Kleemann, P. L. Lewellen, A. L. Borghese, L. J. Antoine, J. Pharm. Sci., 92(6), 1196-1205. DOI: 10.1002/jps.10373
Anhydrates and Hydrates of Olanzapine: Crystallization, Solid-State Characterization, and Structural Relationships, S. M. Reutzel-Edens, J. K. Bush, P. A. Magee, G. A. Stephenson, S. R. Byrn, Cryst. Growth Des., 3(6), 897-907. DOI: 10.1021/cg034055z
2002
Solid-State NMR Spectroscopy of Small Molecules: From NMR Crystallography to the Characterization of Solid Oral Dosage Forms, S. M. Reutzel-Edens, J. K. Bush, American Pharmaceutical Review, 5(2), 112-115.
2001
Characterization of the Solid-State: Quantitative Issues, G. A. Stephenson, S. M. Reutzel-Edens, R. A. Forbes, Advanced Drug Delivery Reviews, 48, 67-90. DOI: 10.1016/S0169-409X(01)00099-0
2000
Molecular Basis for the Stability Relationships Between Homochiral and Racemic Crystals of Tazofelone: A Spectroscopic, Crystallographic, and Thermodynamic Investigation, S. M. Reutzel-Edens, V. A. Russell, L. Yu, J. Chem. Soc., Perkin Trans. 2, 913-924. DOI: 10.1039/A909259E
Crystallization and Polymorphism of Conformationally Flexible Molecules: Problems, Patterns, and Strategies, L. Yu, S. M. Reutzel-Edens, C. A. Mitchell, Org. Proc. Res. & Dev., 4, 396-402. DOI: 10.1021/op000028v
1998
Origins of the Unusual Hygroscopicity Observed in LY297802 Tartrate, S. M. Reutzel, V. A. Russell, J. Pharm. Sci., 87, 1568-1571. DOI: 10.1021/js9801790
Physical Characterization of Polymorphic Drugs: An Integrated Characterization Strategy, L. Yu, S. M. Reutzel, G. A. Stephenson, Pharmaceutical Science and Technology Today Trends Review, 1, 118-127. DOI: 10.1016/S1461-5347(98)00031-5
1994
X-ray Crystallography and Solid-State NMR as Complementary Tools: Characterization of Novel Methylene Meldrum’s Acid Derivatives, M. Zia-Ebrahimi, S. M. Reutzel, D. E. Dorman, L. A. Spangle, J. B. Deeter, Chem. Mater., 6, 822-826. DOI: 10.1021/cm00042a020
1993
Self-Organization of Adenine and Thymine in the Solid State, M. C. Etter, S. M. Reutzel, C. G. Choo, J. Am. Chem. Soc., 115, 4411-4412. DOI: 10.1021/ja00063a089
1992
Evaluation of the Conformational, Hydrogen Bonding, and Crystal Packing Preferences of Acyclic Imides, S. M. Reutzel, M. C. Etter, J. Phys. Org. Chem., 5, 44-54. DOI: 10.1002/poc.610050107
1991
Structures of N-Acetylbenzamide, N-Propionylbenzamide, and N-Butyrylbenzamide and Analysis of Imide Hydrogen-Bond Patterns. M. C. Etter, D. Britton, S. M. Reutzel, Acta Crystallogr., C47, 556-561. DOI: 10.1107/S0108270190006242
Hydrogen-Bond Directed Cocrystallization and Molecular Recognition Properties of Acyclic Imides. M. C. Etter, S. M. Reutzel, J. Am. Chem. Soc., 113, 2586-2598. DOI: 10.1021/ja00007a037
1990
Analysis of Isotropic Chemical Shift Data from High Resolution Solid-State NMR Studies of Hydrogen-Bonded Organic Compounds, M. C. Etter, S. M. Reutzel, G. M. Vojta, J. Mol. Struct., 237, 165-185. DOI: 10.1016/0022-2860(90)80138-A
Crystallography, S. M. Reutzel-Edens, P. Müller, In: Pharmaceutical Crystals: Science and Engineering, T. Li, A. Mattei (editors), John Wiley & Sons, Inc., 2019, 1-46.
Powder Diffraction and Pharmaceuticals, J. Bernstein, S. M. Reutzel-Edens, In: International Tables for Crystallography: Volume H, C. J. Gilmore, J. A. Kaduk (editors) 2019, 767-781.
Hygroscopicity and Hydrates in Pharmaceutical Solids, S. M. Reutzel-Edens, D. E. Braun, A. W. Newman, In: Polymorphism in the Pharmaceutical Industry: Solid Form and Drug Development, R. Hilfiker, M. von Raumer (editors), Wiley-VCH, Verlag GmbH & Co. KGaA, 2018, 159-188.
Solid-State Pharmaceutical Development: Ensuring Stability Through Salt and Polymorph Screening, S. M. Reutzel-Edens, G. A. Stephenson, In: Pharmaceutical Stress Testing: Predicting Drug Degradation, 2nd Edition, S. Baertschi, K. Alsante, R. A Reed (editors), Informa Healthcare, Inc., 2011, 254-285.
Analytical Techniques and Strategies for Salt/Cocrystal Characterization, S. M. Reutzel-Edens, In: Pharmaceutical Salts and Cocrystals, J. Wouters, L. Quéré (editors), The Royal Society of Chemistry Publishing, Cambridge, UK, 2011, 212-246.
NMR Crystallography & Elucidation of Structure-Property Relationships in Crystal Polymorphs, S. M. Reutzel-Edens, In: Engineering of Crystalline Materials Properties: State-of-the Art in Modeling, Design and Applications, 2008, L. Addadi, D. Braga (editors), Springer, 351-374.
The Physical Characterization of Hygroscopicity in Pharmaceutical Solids, S. M. Reutzel-Edens, A. W. Newman, In: Polymorphism in the Pharmaceutical Industry, R. Hilfiker (editor), Wiley-VCH, Weinheim, 2006, 235-258.
Characterizing Structure and Dynamics in Pharmaceutical Solids by Solid-State NMR Spectroscopy, S. M. Reutzel-Edens, J. K. Bush, J. Brus, In: Solid-State Characterization in Pharmaceuticals, A. Zakrzewski, M. Zakrzewski (editors), ASSA, 2006, 326-358.
Crystallization Basic Principles, L. Yu, S. M. Reutzel-Edens, In: Encyclopedia of Food Sciences and Nutrition, Academic Press, 2nd Edition, 2003.
Bicyclic Beta-Lactam / Paraben Complexes, J. Amos, J. M. Indelicato, C. E. Pasini, S. M. Reutzel, U.S. Patent 5412094, issued May 2, 1995. [Download PDF]
Complexes of Cephalosporins and Carbacephalosporins with Parabens, J. Amos, J. M. Indelicato, C. E. Pasini, S. M. Reutzel, U.S. Patent 6001996, issued December 14, 1999. [Download PDF]
Alternate Crystal Form of Tazofelone, M. M. Hansen, A. R. Harkness, S. M. Reutzel, U.S. Patent 6063799, issued May 16, 2000. [Download PDF]
Intermediates and Process for Preparing Olanzapine, C. A. Bunnell, S. D. Larsen, J. R. Nichols, S. M. Reutzel, G. A. Stephenson, U.S. Patent 6020487, issued February 1, 2000. [Download PDF]
Olanzapine Dihydrate D, S. D. Larsen, J. R. Nichols, S. M. Reutzel, G. A. Stephenson, U.S. Patent 6251895, issued June 26, 2001. [Download PDF]
Process for Preparing 10,11-Methanobenzosuberane Derivative, S. M. Reutzel-Edens, M. E. LeTourneau, T. M. Wilson, J. K. Bush, B. E. Huff, U.S. Patent 6521755, issued February 18, 2003. [Download PDF]
Novel crystalline forms of n−[4−[2−(2−amino−4,7−dihydro−4oxo−3h−pyrrolo[2,3−d] pyrimidin−5−yl)ethyl]-benzoyl]−l−glutamic acid and process therefore, S. M. Reutzel-Edens, E. C. Chelius, S. V. Snorek, U.S. Patent 7138521, issued November 21, 2006. [Download PDF]
Novel crystalline forms of (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazine-1-yl]-2-hydroxy-propoxy}quinoline trihydrochloride, J. K. Bush, S. M. Reutzel-Edens, U.S. Patent 7282585, issued October 16, 2007. [Download PDF]
Crystalline forms of 2-[1-(3,5-bis-trifluoromethyl-benzyl)-5-pyridin-4-yl-1H-[1,2,3]triazol-4-yl]-pyridin-3-yl}-(2-chloro-phenyl)methanone, S. Coffey, S. Pedersen, S. M. Reutzel-Edens, S. L. Tameze, U.S. Patent 7381826, issued June 3, 2008. [Download PDF]
Novel crystalline forms of (2R)-anti-5-{3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazine-1-yl]-2-hydroxy-propoxy}quinoline trihydrochloride, S. M. Reutzel-Edens, J. K. Bush, U.S. Patent 7582762, issued September 1, 2009. [Download PDF]
Crystalline 2,5-dione-3-(1-methyl-1H-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1H-indol-3-yl]-1H-pyrrole monohydrochloride, J. K. Bush, M. M. Faul, S. M. Reutzel-Edens, U.S. Patent 8114901, issued February 14, 2012. [Download PDF]
4-{4-[(1E)-4-(2,9-diazaspiro[5.5]undec-2-yl)but-1-en-1-yl]-2-methylbenzyl}-5-(propan-2-yl)-1H-pyrazol-3-yl beta-D-glucopyrano-side acetate, S. M. Reutzel-Edens, U.S. Patent 9573970, issued February 21, 2017. [Download PDF]
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