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Consulting Services

The first, all-important step in transforming a molecule into a medicine is to select the solid form that will be produced as a drug substance, formulated into a drug product, and for solid oral dosage forms, delivered to the patient. Our mission is to help you get it right, preferably the first time.

We can help:

We do this by:

find commercially-viable crystal forms for your drug substance and drug product

select the best form to meet your performance criteria

guide you in how to make, use, and protect your crystal form IP

troubleshoot problems along the way

scoping out your problem or project need to determine if / how we can help

joining your team

helping you build your team of consultants, CROs and other service providers

providing referrals as and when needed

Scientific consulting services

SOLID FORM SCREENING

We design experimental protocols that are fit for purpose, phase appropriate, material sparing, and tailored to the attributes of the drug molecule to find as many crystal forms as possible.

SOLID-STATE CHARACTERIZATION

We devise characterization strategies (methods, measurement conditions) to identify solid forms and establish their phase stability relationships and other key properties.

SOLID FORM SELECTION

We recommend the solid form best suited for a commercial drug product based on a comprehensive assessment of available data.

SOLUBILITY ENABLING SOLID FORMS

We enable toxicology studies through the design and execution of intelligent, material sparing screens for salts, cocrystals and amorphous forms.

SOLID FORM CONTROL

We provide design criteria to achieve polymorph selectivity in crystallization processes and recommendations to maintain the form throughout formulation processing and storage.

in silico SOLID FORM design

We leverage cutting edge modeling and simulation methodology, including crystal structure prediction, and solid form informatics tools to assess polymorph risk.